Search for hepatitis B virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein

@article{Neurath1992SearchFH,
  title={Search for hepatitis B virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein},
  author={A. Robert Neurath and Nathan Strick and P Sproul},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={175},
  pages={461 - 469}
}
The major target organ for hepatitis B virus (HBV) is the liver. However, cells other than hepatocytes, including peripheral blood lymphocytes and monocytes, may become infected with HBV. The cell receptor binding site was assigned to the preS(21-47) segment of the HBV envelope protein. HBV receptors were detected on human liver and hepatoma cells, on B lymphocytes, and, as shown here, on monocytes, and T cell lines, activated by Escherichia coli lipopolysaccharide and concanavalin A… CONTINUE READING

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