Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China

@article{Ren2013SearchFG,
  title={Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China},
  author={Qian Ren and Xueyao Han and Yong Tang and Xiuying Zhang and Xiantong Zou and Xiaoling Cai and Simin Zhang and Lihua Zhang and Hechao Li and Linong Ji},
  journal={Diabetologia},
  year={2013},
  volume={57},
  pages={746-753}
}
The aim of this study was to investigate whether genetic variance can influence the efficacy of glibenclamide in patients with type 2 diabetes. A total of 747 patients with type 2 diabetes was enrolled from the Xiaoke Pills Clinical Trial, which is a double-blind, randomised controlled trial. All the patients had been treated with glibenclamide for 48 weeks, with strict drug dose adjustment and data collection. Treatment failure was confirmed when patients reached the criteria for terminating… CONTINUE READING