Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry.

@article{Desouza2005SearchFC,
  title={Search for cancer markers from endometrial tissues using differentially labeled tags iTRAQ and cICAT with multidimensional liquid chromatography and tandem mass spectrometry.},
  author={Leroi V Desouza and Georg Diehl and Mary Joe Rodrigues and Jingzhong Guo and Alexander D. Romaschin and Terence J. Colgan and K. W. Michael Siu},
  journal={Journal of proteome research},
  year={2005},
  volume={4 2},
  pages={377-86}
}
A total of nine potential markers for endometrial cancer (EmCa) have been discovered and identified from endometrial tissue homogenates using a combination of differentially labeled tags, iTRAQ and cICAT, with multidimensional liquid chromatography and tandem mass spectrometry. The tissues were snap frozen in liquid nitrogen within 15-20 min after devitalization. Samples for proteomic analysis were treated with protease inhibitors before processing. Marker proteins that were overexpressed in… CONTINUE READING
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