Search and clustering orders of magnitude faster than BLAST

  title={Search and clustering orders of magnitude faster than BLAST},
  author={Robert C. Edgar},
  volume={26 19},
MOTIVATION Biological sequence data is accumulating rapidly, motivating the development of improved high-throughput methods for sequence classification. RESULTS UBLAST and USEARCH are new algorithms enabling sensitive local and global search of large sequence databases at exceptionally high speeds. They are often orders of magnitude faster than BLAST in practical applications, though sensitivity to distant protein relationships is lower. UCLUST is a new clustering method that exploits USEARCH… CONTINUE READING
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