Seamless Oncology-Drug Development.

  title={Seamless Oncology-Drug Development.},
  author={Tatiana M. Prowell and Marc R. Theoret and Richard Pazdur},
  journal={The New England journal of medicine},
  volume={374 21},
safety, tolerability, and dose; phase 2 trials then explored the drug’s activity in a variety of cancers; and phase 3 trials compared the new drug with existing treatments and served as the basis for regulatory approval. Advances in our understanding of cancer biology in the past decade have led to both development of more effective drugs and improved patient selection made possible by early biomarker discovery and companion diagnostic development. Desire for early access to transformative new… CONTINUE READING
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