Sealing the gap between nuclear DNA damage and longevity.

@article{Schumacher2009SealingTG,
  title={Sealing the gap between nuclear DNA damage and longevity.},
  author={Bj{\"o}rn Schumacher and Jan H. J. Hoeijmakers and George A Garinis},
  journal={Molecular and cellular endocrinology},
  year={2009},
  volume={299 1},
  pages={112-7}
}
A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect of the aging process. Here, we review a number of mouse models for progeroid syndromes that are caused by inherited defects in nucleotide excision repair and are characterized by rapid onset of aging symptoms and premature death. We argue that alterations in genome maintenance pathways impact complex physiological processes that may… CONTINUE READING

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