Sealing one's fate: control of cell death in neurons.

@article{Bergeron1998SealingOF,
  title={Sealing one's fate: control of cell death in neurons.},
  author={Louise Bergeron and Junying Yuan},
  journal={Current opinion in neurobiology},
  year={1998},
  volume={8 1},
  pages={55-63}
}
BCL-2 family members and caspases are essential components of the death machinery in neurons. Identification of Apaf-1 as the mammalian homologue of Caenorhabditis elegans ced-4 provided the final proof of the complete conservation of the C. elegans programmed cell death pathway in mammals. When neurons are deprived of trophic factors, a sequence of events is initiated, which includes a reduction in macromolecule synthesis, elevation of c-Jun and cyclin D1, and activation of BAX. The final… CONTINUE READING

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