Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

@inproceedings{Klinger2012SeaanemoneTA,
  title={Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons},
  author={Alexandra B. Klinger and Mirjam J. Eberhardt and Andrea S. Link and Barbara Namer and Lisa K Kutsche and E Theresa Schuy and Ruth Sittl and Tali Hoffmann and Christian Alzheimer and Tobias Huth and Richard W. Carr and Angelika Lampert},
  booktitle={Molecular pain},
  year={2012}
}
BACKGROUND Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain disorder (PEPD). One characteristic of these mutations is slowed fast-inactivation kinetics, which may give rise to resurgent sodium currents. It is long known that toxins from Anemonia sulcata, such as ATX-II, slow fast inactivation and skin contact for example during diving leads to various symptoms such as pain and itch. Here, we… CONTINUE READING
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