Se-(methyl)selenocysteine (MSC) potentiates the antitumor activity of irinotecan against human tumor xenografts and protects against drug induced toxicity.


2068 Background: Selenium compounds induce specific molecular and cell cycle modulation and are in clinical development as chemopreventive agents. The effects of MSC on the antitumor efficacy and toxicity of irinotecan (IR) were evaluated in nude mice bearing HCT-8 & HT-29 colon and A253 & FaDu head and neck cancers. METHODS IR was administered by i.v… (More)