Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe.

@article{SugiokaSugiyama2011Sde2AN,
  title={Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe.},
  author={Rie Sugioka-Sugiyama and Tomoyasu Sugiyama},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={406 3},
  pages={444-8}
}
Telomeres, specialized domains assembled at the ends of linear chromosomes, are essential for genomic stability in eukaryotes. The formation and maintenance of telomeres are governed by numerous factors such as telomeric repeats, telomere-binding proteins, heterochromatin proteins, and telomerase. Here, we report Sde2, a novel nuclear protein essential for telomeric silencing and genomic stability in the fission yeast Schizosaccharomyces pombe. A deficiency in sde2 results in the derepression… CONTINUE READING

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