Scythe: a novel reaper-binding apoptotic regulator.

  title={Scythe: a novel reaper-binding apoptotic regulator.},
  author={Ken Thress and William Henzel and W Shillinglaw and Sally Kornbluth},
  journal={The EMBO journal},
  volume={17 21},
Reaper is a central regulator of apoptosis in Drosophila melanogaster. With no obvious catalytic activity or homology to other known apoptotic regulators, reaper's mechanism of action has been obscure. We recently reported that recombinant Drosophila reaper protein induced rapid mitochondrial cytochrome c release, caspase activation and apoptotic nuclear fragmentation in extracts of Xenopus eggs. We now report the purification of a 150 kDa reaper-interacting protein from Xenopus egg extracts… CONTINUE READING