Scutellaria baicalensis Ameliorates Acute Lung Injury by Suppressing Inflammation In Vitro and In Vivo.
@article{Chen2017ScutellariaBA, title={Scutellaria baicalensis Ameliorates Acute Lung Injury by Suppressing Inflammation In Vitro and In Vivo.}, author={Jian-Jung Chen and Chung-Chun Huang and Heng-yuan Chang and Pei-Ying Li and Yu-Chia Liang and Jeng‐Shyan Deng and Shyh-shyun Huang and Guan-Jhong Huang}, journal={The American journal of Chinese medicine}, year={2017}, volume={45 1}, pages={ 137-157 } }
Scutellaria baicalensis has been widely used as both a dietary ingredient and traditional herbal medicine in Taiwan to treat inflammation, cancer, and bacterial and viral infections of the respiratory tract and gastrointestinal tract. This paper aims to investigate the in vitro and in vivo anti-inflammatory effects of S. baicalensis. In HPLC analysis, the fingerprint chromatogram of the water extract of S. baicalensis (WSB) was established. The anti-inflammatory effects of WSB were…
32 Citations
p-Coumaric-Acid-Containing Adenostemma lavenia Ameliorates Acute Lung Injury by Activating AMPK/Nrf2/HO-1 Signaling and Improving the Anti-oxidant Response.
- Biology, MedicineThe American journal of Chinese medicine
- 2019
It is suggested that EAAL is a potential therapeutic agent to treat inflammatory disorders.
Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model
- Biology, MedicineEvidence-based complementary and alternative medicine : eCAM
- 2018
SB could significantly improve the condition of airway remodeling by inhibiting airway inflammation and partially quenching TGF-β and MMPs via PI3K/AKT/NF-κB pathway.
Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways
- BiologyEvidence-based complementary and alternative medicine : eCAM
- 2018
The results from this study indicate AVA has anti-inflammatory effects in vivo and AVA is a potential model for the development of health food.
Inhibitory Effects of Scutellaria baicalensis Root Extract on Linoleic Acid Hydroperoxide-induced Lung Mitochondrial Lipid Peroxidation and Antioxidant Activities
- Medicine, ChemistryMolecules
- 2019
Baicalein and the EtOAc extract of SBR may be efficient in conferring ROS damage protection and inhibiting LHP-induced LPO in rat lung mitochondria, and their use as antioxidant therapy for respiration infections, nutrition supplements, and lead compounds in pharmaceuticals is investigated.
Scutellaria baicalensis and Cancer Treatment: Recent Progress and Perspectives in Biomedical and Clinical Studies.
- Biology, ChemistryThe American journal of Chinese medicine
- 2018
A more thorough view of the last 10 years of the anticancer activity of S. baicalensis is provided to link traditional use with modern research and to highlight recently discovered molecular mechanisms.
Perilla Fruit Water Extract Attenuates Inflammatory Responses and Alleviates Neutrophil Recruitment via MAPK/JNK-AP-1/c-Fos Signaling Pathway in ARDS Animal Model
- Biology, MedicineEvidence-based complementary and alternative medicine : eCAM
- 2022
Perilla fruit water extract (PFWE) attenuated pro-inflammatory cytokine and chemokine levels and downregulated neutrophil recruitment through the MAPK/JNK-AP-1/c-Fos pathway and can be a potential drug to assist the treatment of ARDS.
Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms
- ChemistryDARU Journal of Pharmaceutical Sciences
- 2022
Scutellaria baicalensis (SB) has been traditionally used to combat a variety of conditions ranging from ischemic heart disease to cancer. The protective effects of SB are due to the action of two…
Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis
- Medicine, BiologyWorld journal of gastroenterology
- 2017
In the rat model of CARE, BHSST can suppress development of esophageal mucosal ulceration via regulation of reactive oxygen species-dependent apoptosis and exerted an anti-apoptotic effect.
Baicalin Inhibits Inflammatory Responses to Interleukin-1β Stimulation in Human Chondrocytes.
- Biology
- 2017
It is found that BA treatment led to remarkable reductions of OA-related proinflammatory gene expressions, including interleukin (IL)-6, tumor necrosis factor (TNF), chemokine (C-X-C motif) ligand 1 (CXCL1), and CXCL10.
Retracted: Baicalin relieves lipopolysaccharide‐evoked inflammatory injury through regulation of miR‐21 in H9c2 cells
- BiologyPhytotherapy research : PTR
- 2020
Investigation of the influences of Baicalin on Lipopolysaccharide (LPS)‐evoked H9c2 cells found that LPS stimulation induced cell apoptosis and upregulation of IL‐6 and TNF‐α.
References
SHOWING 1-10 OF 30 REFERENCES
Anti-oxidative and anti-inflammatory effects of Lobelia chinensis in vitro and in vivo.
- Biology, MedicineThe American journal of Chinese medicine
- 2015
The results suggested that L. chinensis exhibited an anti-inflammatory effect through the NF-κB pathways.
Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.
- Medicine, BiologyJournal of agricultural and food chemistry
- 2014
This is the first investigation in which methanol extract of AC inhibited acute lung edema effectively, which may provide a potential target for treating ALI.
Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway.
- Medicine, BiologyJournal of ethnopharmacology
- 2015
Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-κB signaling pathway.
- Medicine, BiologyInternational immunopharmacology
- 2015
The total alkaloids of Aconitum tanguticum protect against lipopolysaccharide-induced acute lung injury in rats.
- Biology, MedicineJournal of ethnopharmacology
- 2014
Emodin Ameliorates LPS-Induced Acute Lung Injury, Involving the Inactivation of NF-κB in Mice
- Biology, MedicineInternational journal of molecular sciences
- 2014
Evaluated data indicates that emodin potently inhibits LPS-induced pulmonary inflammation, pulmonary edema and MCP-1 and E-selectin expression, and that these effects were very likely mediated by inactivation of NF-κB in mice.
Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways
- Medicine, BiologyRespiratory Physiology & Neurobiology
- 2015
Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response.
- Biology, ChemistryMolecular medicine reports
- 2015
Investigation of the effects of Scutellariae Radix on low-density lipoprotein (LDL) oxidation and inflammation in macrophages suggested that SR may be a potential therapeutic agent for the treatment of atherosclerosis.
Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via JNK/NF-κB signaling pathway.
- BiologyThe American journal of Chinese medicine
- 2014
The leaves of Nelumbo nucifera Gaertn and its major components quercetin and catechin exhibit anti-inflammatory activities by inhibiting the JNK- and NF-κB-regulated pathways and could therefore be an useful anti- inflammation agent.
Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima.
- MedicineJournal of ethnopharmacology
- 2013