Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation*
@article{Schubert2001ScurfinA, title={Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation*}, author={Lisa A. Schubert and Eric Jeffery and Yi Zhang and Fred Ramsdell and Steven F. Ziegler}, journal={The Journal of Biological Chemistry}, year={2001}, volume={276}, pages={37672 - 37679} }
We have recently identified and clonedFoxp3, the gene defective in mice with thescurfy mutation. The immune dysregulation documented in these mice and in humans with mutations in the orthologous gene indicates that the foxp3 gene product, scurfin, is involved in the regulation of T cell activation and differentiation. The autoimmune state observed in these patients with the immune dysregulation polyendocrinopathy, enteropathy, X-linked syndrome, or X-linked autoimmunity-allergic dysregulation…
566 Citations
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A critical role for the Foxp3 gene product in the function of the immune system is indicated, with both the number and functionality of peripheral T cells under the aegis of the scurfin protein.
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