Scrib Controls Cdc42 Localization and Activity to Promote Cell Polarization during Astrocyte Migration

Abstract

BACKGROUND Mammalian Scribble (Scrib) plays a conserved role in polarization of epithelial and neuronal cells. Polarization is essential for migration of a variety of cell types; however, the function of Scrib in this context remains unclear. Scrib has been shown to interact with betaPIX, a guanine nucleotide exchange factor for the small GTPases Rac and… (More)
DOI: 10.1016/j.cub.2006.10.026

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@article{Osmani2006ScribCC, title={Scrib Controls Cdc42 Localization and Activity to Promote Cell Polarization during Astrocyte Migration}, author={Na{\"{e}l Osmani and Nicolas Vitale and Jean-Paul Borg and Sandrine Etienne-Manneville}, journal={Current Biology}, year={2006}, volume={16}, pages={2395-2405} }