Screw motion regulates multiple functions of T4 phage protein gene product 5 during cell puncturing.

@article{Nishima2011ScrewMR,
  title={Screw motion regulates multiple functions of T4 phage protein gene product 5 during cell puncturing.},
  author={Wataru Nishima and Shuji Kanamaru and Fumio Arisaka and Akio Kitao},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 34},
  pages={13571-6}
}
Bacteriophage T4 penetrates the outer membrane of Escherichia coli using a multifunctional device composed of a gene product 5 (gp5) protein trimer. We report that gp5 sequentially exerts distinct functions along the course of penetration stages induced by screw motion. A triple-stranded β-helix of gp5 acts as a cell-puncturing drill bit to make a hole on the membrane and then send the lipids upward efficiently by strong charge interactions. The gp5 lysozyme domains, which degrade the… CONTINUE READING

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