Screening of xenobiotics by ultra-performance liquid chromatography-mass spectrometry using in-source fragmentation at increasing cone voltages: library constitution and an evaluation of spectral stability.

@article{Humbert2010ScreeningOX,
  title={Screening of xenobiotics by ultra-performance liquid chromatography-mass spectrometry using in-source fragmentation at increasing cone voltages: library constitution and an evaluation of spectral stability.},
  author={Luc Humbert and Frederic Grisel and Camille Richeval and Michel Lhermitte},
  journal={Journal of analytical toxicology},
  year={2010},
  volume={34 9},
  pages={571-80}
}
In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a fast (15 min) comprehensive screening method for 500 toxicologically relevant analytes based on ultra-performance liquid chromatography (UPLC) coupled with a quadrupole mass spectrometer (MS) system operated in full scan mode. Data were acquired using both positive and negative electrospray ionization by scanning across the range m/z 80-650. For… CONTINUE READING