Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins

@article{Kato2004ScreeningOT,
  title={Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins},
  author={Yukio Kato and Kazuhiro Yoshida and Chizuru Watanabe and Yoshimichi Sai and Akira Tsuji},
  journal={Pharmaceutical Research},
  year={2004},
  volume={21},
  pages={1886-1894}
}
Purpose. Xenobiotic transporters have been proposed to be involved in membrane penetration of various therapeutic agents. As little information is available on molecular mechanism of their functional regulation, we have attempted to clarify the protein-protein interactions of such transporters as a first step to identify their regulators. Methods. Yeast two-hybrid screening was performed to examine the interaction between carboxylic terminus of various xenobiotic transporters and PDZ (PSD95… CONTINUE READING

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