Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins

  title={Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins},
  author={Y. Kato and K. Yoshida and C. Watanabe and Y. Sai and A. Tsuji},
  journal={Pharmaceutical Research},
  • Y. Kato, K. Yoshida, +2 authors A. Tsuji
  • Published 2004
  • Medicine, Chemistry
  • Pharmaceutical Research
  • AbstractPurpose. Xenobiotic transporters have been proposed to be involved in membrane penetration of various therapeutic agents. As little information is available on molecular mechanism of their functional regulation, we have attempted to clarify the protein-protein interactions of such transporters as a first step to identify their regulators. Methods. Yeast two-hybrid screening was performed to examine the interaction between carboxylic terminus of various xenobiotic transporters and PDZ… CONTINUE READING
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    Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*
    • 641
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    • 778
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    • 482
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    • 232
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    • 224
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    • 171
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