Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition

@article{Slanc2009ScreeningOS,
  title={Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition},
  author={Petra Slanc and Bojan Doljak and Samo Kreft and Mojca Lunder and Damjan Jane{\vs} and B. Strukelj},
  journal={Phytotherapy Research},
  year={2009},
  volume={23}
}
Lipids are important components in human nutrition; however, their increased intake contributes to the development of obesity and can lead to multiple long‐term complications. Pancreatic lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) is a key enzyme for the absorption of dietary triglycerides. Interference with fat hydrolysis results in the reduced utilization of ingested lipids, therefore inhibition of lipases decreases fat absorption. Extracts from 106 species of medicinal plants… 
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111 Citations
Background Citations
30
Methods Citations
10
Results Citations
1

111 Citations

Wild Mediterranean Dietary Plants as Inhibitors of Pancreatic Lipase

In this study, the findings do not show any relationship between lipase inhibitory activity and total phenolic content.

Effects of Fruit Extracts on Pancreatic Lipase Activity in Lipid Emulsions

Consumption of chokeberry, red gooseberry and red currant fruits may be a new dietary option for reduction of fat absorption via inhibition of pancreatic lipase in lipid emulsion models.

Inhibition of Pancreatic Lipase by Culinary Plant Extracts

According to the results; green apple, green tea and avocado extracts had the highest antilipase activities and may be involved in weight control programs.

Medicinal Plants Traditionally Used for Treatment of Obesity and Diabetes Mellitus – Screening for Pancreatic Lipase and α‐Amylase Inhibition

It is shown that the methanolic extract of Hibiscus sabdariffa L. (Malvaceae) showed high inhibitory activities to PL and α‐amylase, and a priority list of interesting plants for further study with respect to the treatment of obesity and associated diseases is provided.

In vitro inhibitory effect on digestive enzymes and antioxidant potential of commonly consumed fruits.

Among fruits tested, blue honeysuckle and red gooseberry exhibited the highest inhibitory activity with respect to the carbohydrate degrading enzymes, while lingonberry had the strongest anti-lipase activity.

The In Vitro Inhibitory Effect of Selected Asteraceae Plants on Pancreatic Lipase Followed by Phenolic Content Identification through Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS)

The presented approach combines in vitro bioactivity measurements to high-end metabolomics to identify phenolic compounds with potential medicinal and/or dietary applications to identify PNLIP inhibitory effect of 33 plants belonging in the Asteraceae botanical family.

Polyphenolic Compounds as Pancreatic Lipase Inhibitors.

A structural comparison of potent inhibitors shows an increased inhibitory effect depending on number and position of phenolic hydroxyl groups, degree of polymerization and elimination of glycosylation during digestion.

Camellia sinensis extract inhibits in vitro pancreatic lipase and has preventive effect on obesity in female rat fed a high-fat diet

C. sinensis extract is certainly a promising alternative for preventive obesity treatment, since biochemical parameters analyzed showed significantly, reduction in the serum triglycerides levels and significantly decreased the LDL-cholesterol basal levels when compared with animals that did not receive a fat diet.

In Vitro Anti-obesity , Antioxidant and Anti-Inflammatory Studies on the Selected Medicinal Plants

Evaluated antiobesity, antioxidant and antiinflammatory activities of four medicinal plants namely Acorus calamus, Alpinia galanga, Cinnamomum zeylanicum and Piper cubeba conclude that preparation of herbal formulation using the investigated plant drugs will leads to the development of effective antiobese drug.

Inhibition of hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituents

The current manuscript summarizes a significant amount of work that was undertaken to identify plant species native to Jordan with potential HSL and pancreatic lipase (PL) inhibitory activities and demonstrated in vitroinhibitory effects of R. officnalis on both H SL and PL in a dose dependent manner.
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References

SHOWING 1-10 OF 11 REFERENCES

Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.

  • L. Bravo
  • Chemistry, Medicine
    Nutrition reviews
  • 1998
An overview of the nutritional effects of the main groups of polyphenolic compounds, including their metabolism, effects on nutrient bioavailability, and antioxidant activity, is offered, as well as a brief description of the chemistry ofpolyphenols and their occurrence in plant foods.

Plant polyphenols: biologically active compounds or non-selective binders to protein?

Polyphenols, astringency and proline-rich proteins.

Screening of selected plant extracts for in vitro inhibitory activity on HIV-1 reverse transcriptase (HIV-1 RT).

Methanolic-aqueous extracts of 70 plants were investigated for their ability to inhibit HIV-1 reverse transcriptase activity in vitro and new leading structures are expectable from the future isolation and characterization of these compounds.

Lipase activity measured in serum by a continuous-monitoring pH-Stat technique--an update.

Using recent knowledge regarding the roles of colipase, bile acids, Ca2+, and emulsifiers, a previously published pH-Stat method for lipase activity measurements is optimized and correlates well with the optimized SingleVial method of Boehringer Mannheim Diagnostics and the immunochemical assay of Beckman Instruments, Inc.

Dietary Effects on Cardiovascular Disease Risk Factors: Beyond Saturated Fatty Acids and Cholesterol

Dietary interventions that lower LDL-C without affecting HDL-C levels are summarized, including soy protein, soluble fiber, soy lecithin and plant sterols, which reduce the risk of CVD without changes in lipoprotein cholesterol.

Purification and characterization of Pseudomonas fluorescens SIK W1 lipase expressed in Escherichia coli.

Influence of acetonylgeraniin, a hydrolyzable tannin from Euphoria longana, on orthostatic hypotension in a rat model.

A direct release of NA from the noradrenergic nerve terminals by acetonylgeraniin seems responsible for the reversing of orthostatic hypotension.

Fat and cholesterol in the diet of infants and young children: implications for growth, development, and long-term health.

Long-term pharmacotherapy for obesity.

Clinical trials have shown that both drugs can induce and maintain weight loss, even in patients with comorbid conditions such as hypertension or type 2 diabetes, however, their use must be combined with behavior modification and a structured meal plan, for patients to reap the full benefits of such treatment.