Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition

  title={Screening of selected food and medicinal plant extracts for pancreatic lipase inhibition},
  author={Petra Slanc and Bojan Doljak and Samo Kreft and Mojca Lunder and Damjan Jane{\vs} and B. Strukelj},
  journal={Phytotherapy Research},
Lipids are important components in human nutrition; however, their increased intake contributes to the development of obesity and can lead to multiple long‐term complications. Pancreatic lipase (triacylglycerol acylhydrolase, EC is a key enzyme for the absorption of dietary triglycerides. Interference with fat hydrolysis results in the reduced utilization of ingested lipids, therefore inhibition of lipases decreases fat absorption. Extracts from 106 species of medicinal plants… 

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In this study, the findings do not show any relationship between lipase inhibitory activity and total phenolic content.

Effects of Fruit Extracts on Pancreatic Lipase Activity in Lipid Emulsions

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According to the results; green apple, green tea and avocado extracts had the highest antilipase activities and may be involved in weight control programs.

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Among fruits tested, blue honeysuckle and red gooseberry exhibited the highest inhibitory activity with respect to the carbohydrate degrading enzymes, while lingonberry had the strongest anti-lipase activity.

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A structural comparison of potent inhibitors shows an increased inhibitory effect depending on number and position of phenolic hydroxyl groups, degree of polymerization and elimination of glycosylation during digestion.

Camellia sinensis extract inhibits in vitro pancreatic lipase and has preventive effect on obesity in female rat fed a high-fat diet

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In Vitro Anti-obesity , Antioxidant and Anti-Inflammatory Studies on the Selected Medicinal Plants

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Inhibition of hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituents

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Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.

  • L. Bravo
  • Chemistry, Medicine
    Nutrition reviews
  • 1998
An overview of the nutritional effects of the main groups of polyphenolic compounds, including their metabolism, effects on nutrient bioavailability, and antioxidant activity, is offered, as well as a brief description of the chemistry ofpolyphenols and their occurrence in plant foods.

Polyphenols, astringency and proline-rich proteins.

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Lipase activity measured in serum by a continuous-monitoring pH-Stat technique--an update.

Using recent knowledge regarding the roles of colipase, bile acids, Ca2+, and emulsifiers, a previously published pH-Stat method for lipase activity measurements is optimized and correlates well with the optimized SingleVial method of Boehringer Mannheim Diagnostics and the immunochemical assay of Beckman Instruments, Inc.

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A direct release of NA from the noradrenergic nerve terminals by acetonylgeraniin seems responsible for the reversing of orthostatic hypotension.

Long-term pharmacotherapy for obesity.

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