Screening of pharmacological agents given peripherally with respect to TCDD-induced wasting syndrome in Long-Evans rats.

@article{Pohjanvirta1988ScreeningOP,
  title={Screening of pharmacological agents given peripherally with respect to TCDD-induced wasting syndrome in Long-Evans rats.},
  author={Raimo Pohjanvirta and Jouko Tuomisto and K Vikkula},
  journal={Pharmacology & toxicology},
  year={1988},
  volume={63 4},
  pages={240-7}
}
A salient sign of fatal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication is dramatic body weight loss accompanied by hypophagia. Yet, the nature of this wasting syndrome is unknown. As all of the current leptogenic (weight reducing) drugs exert their action by affecting aminergic neurotransmission, this study set out to screen the reversibility of TCDD-induced anorexia with the following agents modulating aminergic neurotransmission: amphetamine, amperozide, chlordiazepoxide, clonidine… CONTINUE READING