Screening of natural compounds for inhibitory activity on colon cancer cell migration.

@article{Ogasawara2001ScreeningON,
  title={Screening of natural compounds for inhibitory activity on colon cancer cell migration.},
  author={Masaru Ogasawara and Toshiyuki Matsubara and H. Suzuki},
  journal={Biological \& pharmaceutical bulletin},
  year={2001},
  volume={24 6},
  pages={
          720-3
        }
}
We examined the effects of 75 kinds of natural compounds, such as alkaloids, phenylpropanoids, flavonoids, steroids and terpenoids on the in vitro migration and proliferation of colon 26-L5 cells, in comparison with anti-cancer drugs used for chemotherapy. Twenty-three of the 75 compounds inhibited markedly tumor cell migration. Among the 23 compounds, evodiamine showed the most potent and selective inhibitory activity on tumor cell migration with an IC50 value of 1.25 microg/ml, which was… Expand
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