Screening of maternal serum for fetal Down's syndrome in the first trimester.

@article{Haddow1998ScreeningOM,
  title={Screening of maternal serum for fetal Down's syndrome in the first trimester.},
  author={James E. Haddow and Glenn E Palomaki and George J. Knight and John E. Williams and Wayne A Miller and Anthony J. Johnson},
  journal={The New England journal of medicine},
  year={1998},
  volume={338 14},
  pages={955-61}
}
BACKGROUND Screening of maternal serum to identify fetuses with Down's syndrome is now routinely offered during the second trimester of pregnancy. Prenatal screening by means of serum assays or ultrasonographic measurements, either alone or in combination, may also be possible in the first trimester. METHODS We measured serum alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin (hCG), the free beta subunit of hCG, and pregnancy-associated protein A in 4412 women (82 percent… CONTINUE READING
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