Screening of isoquinoline alkaloids and their derivatives for antibacterial and antifungal activities.

  title={Screening of isoquinoline alkaloids and their derivatives for antibacterial and antifungal activities.},
  author={I L Tsai and Y F Liou and Sarah T Lu},
  journal={Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences},
  volume={5 3},
  • I. TsaiY. LiouS. Lu
  • Published 1 March 1989
  • Chemistry, Biology, Medicine
  • Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences
A screening test of antimicrobial activities for some of the isoquinoline alkaloids and their first and second Hofmann elimination products was conducted in this study. Results showed that (+)-actinodaphnine (1), (+)-N-Me-actinodaphnine (2), (+)-anonaine (17), (-)-xylopine (19) and (-)-N-Me-xylopine MeI (20), had the strongest inhibitory activities against three G(+) bacteria (Bacillus cereus, Micrococcus sp. and Staphylococcus aureus) MIC greater than or equal to 50 micrograms/ml). Whereas… 

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