Screening of isoquinoline alkaloids and their derivatives for antibacterial and antifungal activities.

@article{Tsai1989ScreeningOI,
  title={Screening of isoquinoline alkaloids and their derivatives for antibacterial and antifungal activities.},
  author={I L Tsai and Y F Liou and Sarah T Lu},
  journal={Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences},
  year={1989},
  volume={5 3},
  pages={
          132-45
        }
}
  • I. TsaiY. LiouS. Lu
  • Published 1 March 1989
  • Chemistry, Biology, Medicine
  • Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences
A screening test of antimicrobial activities for some of the isoquinoline alkaloids and their first and second Hofmann elimination products was conducted in this study. Results showed that (+)-actinodaphnine (1), (+)-N-Me-actinodaphnine (2), (+)-anonaine (17), (-)-xylopine (19) and (-)-N-Me-xylopine MeI (20), had the strongest inhibitory activities against three G(+) bacteria (Bacillus cereus, Micrococcus sp. and Staphylococcus aureus) MIC greater than or equal to 50 micrograms/ml). Whereas… 

Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action from 1979 to 2022.

Chemical Constituents of Neolitsea parvigemma and Neolitsea konishii

Twenty-four compounds including three flavonoids, kaempferol-3-O-rhamnoside (1), quercetin-3-O-rhamnoside (2), and taxifolin-3-O-rhamnoside (3); three ferulates, docosanylferulate (4),

Alkaloid profiling and antimicrobial activities of Papaver glaucum and P. decaisnei

Results indicate that P. glaucum and P. decaisnei are promising sources of alkaloids that could further be investigated for medicinal purposes.

Antimicrobially Active Alkaloids

There has long been an interest in screening plants and the derived natural products for biological activity, with the aim of producing new drugs, and studies of antimicrobially active plants have resulted in identifying many alkaloids that have such activity.

Simultaneous quantification of 11 isoquinoline alkaloids in Corydalis impatiens (Pall.) Fisch by HPLC.

A new, simple, and multiple-component quantification method was developed for the simultaneous quantification of 11 isoquinoline alkaloids including capnoidine, chelianthifoline, bicuculline, protopine, isoapocavidine, apocavidines, cavidine and tetrahydroepiberberine in Corydalis impatiens.

Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts.

This study reinforced that A. squamosa presents a remarkable phytomedicinal potential and revealed that its antimicrobial mechanism of action is related to bacterial membrane destabilization.

Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla

Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values comparable with the reference standard, chloroquine.