Screening of herbal constituents for aromatase inhibitory activity.

  title={Screening of herbal constituents for aromatase inhibitory activity.},
  author={S Paoletta and Glyn B Steventon and Dirk Wildeboer and Thomas M. Ehrman and Peter J. Hylands and David J. Barlow},
  journal={Bioorganic & medicinal chemistry},
  volume={16 18},
Random Forest screening of the phytochemical constituents of 240 herbs used in traditional Chinese medicine identified a number of compounds as potential inhibitors of the human aromatase enzyme (CYP19). Molecular modelling/docking studies indicated that three of these compounds (myricetin, liquiritigenin and gossypetin) would be likely to form stable complexes with the enzyme. The results of the virtual screening studies were subsequently confirmed experimentally, by in vitro (fluorimetric… CONTINUE READING