Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.

@article{Dong1996ScreeningOC,
  title={Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.},
  author={Qian Dong and Fr. Brucker-Davis and Bruce D. Weintraub and Robert Christian Smallridge and Frances E. Carr and James F. Battey and Allen M. Spiegel and Andrew Shenker},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 3},
  pages={
          1134-40
        }
}
Activating mutations encoding substitutions at positions Arg201 and Gln227 of the alpha-subunit of the stimulatory G protein. G10 have been found in about 40% of pituitary somatotroph tumors. Although the etiology of thyrotroph adenomas is unknown, their autonomous behavior and blunted response to stimulatory hypothalamic hormone superficially resemble those of somatotroph tumors. We hypothesized that a subset of thyrotroph tumors might be caused by dominant somatic mutations that lead to… CONTINUE READING
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