Screening of active ingredients of herbal medicine for interaction with CYP450 3A4.

@article{Lee2007ScreeningOA,
  title={Screening of active ingredients of herbal medicine for interaction with CYP450 3A4.},
  author={Shui Shan Lee and Baizhong Zhang and Monica Kai He and V. S. Chang and Hsiang Fu Kung},
  journal={Phytotherapy research : PTR},
  year={2007},
  volume={21 11},
  pages={
          1096-9
        }
}
A two-step algorithm is adopted in the screening of herbal species which possess significant inhibitory effects on cytochrome P450 3A4 (CYP450 3A4). The algorithm comprises an initial stage of high throughput screening with Herbochip for the identification of herbal fractions that exhibit interactions with CYP450 3A4. Fifty commonly used TCM species were screened with seven showing a positive signal reflecting interaction. In the inhibition assays that followed, six of the seven species gave a… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Similar Papers

Loading similar papers…