Screening of SMG7-binding peptides by combination of phage display and docking simulation analysis.

Abstract

We screened SMG7-binding peptides with phage display and docking simulation analysis. Although a consensus motif was absent in the phage display-derived candidates, we succeeded to find a peptide CDDRPPKSC, which can bind specifically to SMG7. We conclude that docking simulation helps to find high-affinity peptides efficiently, even if the phage display-screened candidates lack a consensus region.

Cite this paper

@article{Zahed2009ScreeningOS, title={Screening of SMG7-binding peptides by combination of phage display and docking simulation analysis.}, author={Muhammed Zahed and Toshikazu Suzuki and Akiko Suganami and Hajime Sugiyama and Kazuo Harada and Masaki Takiguchi and Yutaka Tamura and Nobuo Suzuki}, journal={Protein and peptide letters}, year={2009}, volume={16 3}, pages={301-5} }