Screening of Photosensitizers by Chemiluminescence Monitoring of Formation Dynamics of Singlet Oxygen during Photodynamic Therapy.

Abstract

Finding an efficient photosensitizer is crucial in ensuring a therapeutic effect of photodynamic treatment. Currently, screening of photosensitizers during photodynamic therapy is achieved by evaluating the total yield of singlet oxygen ((1)O2), rather than monitoring the formation dynamics of (1)O2. (1)O2-based chemiluminescence (CL) is a suitable method to directly monitor the generated amount of (1)O2. Herein, the tetraphenylethene-sodium dodecyl sulfonate surfactant with aggregation-induced emission characteristics can remarkably amplify the intrinsic CL emission from (1)O2 by integrating its micellar microenvironment with a CL energy acceptor effect in a cage-like structure. We present a new luminescence platform for the rapid screening of photosensitizers by monitoring the formation dynamics of (1)O2 during photodynamic therapy. This study will not only be critical in optimizing the irradiation time during photodynamic therapy but also open a new door to the discovery of efficient photosensitizers.

Cite this paper

@article{Zou2016ScreeningOP, title={Screening of Photosensitizers by Chemiluminescence Monitoring of Formation Dynamics of Singlet Oxygen during Photodynamic Therapy.}, author={Fengjuan Zou and Wenjuan Zhou and Weijiang Guan and Chao Lu and Ben Zhong Tang}, journal={Analytical chemistry}, year={2016}, volume={88 19}, pages={9707-9713} }