Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis

@inproceedings{Liu2016ScreeningOH,
  title={Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis},
  author={Shiguo Liu and Jian Chai and Guohua Zheng and Huichao Li and Deguo Lu and Yin-lin Ge},
  booktitle={Journal of clinical research in pediatric endocrinology},
  year={2016}
}
OBJECTIVE Congenital hypothyroidism (CH) is a frequent neonatal endocrine disease with an incidence of about 1:2500 worldwide. Although thyroid dysgenesis (TD) is the most frequent cause of CH cases, its pathogenesis remains unclear. The aim of this study was to screen the hematopoietically-expressedhomeobox gene (HHEX) mutations in Chinese children with TD. METHODS Genomic deoxyribonucleic acid was extracted from peripheral blood leukocytes in 234 TD patients from Shandong Province… CONTINUE READING