Screening methods to identify indole derivatives that protect against reactive oxygen species induced tryptophan oxidation in proteins.

@article{Grewal2014ScreeningMT,
  title={Screening methods to identify indole derivatives that protect against reactive oxygen species induced tryptophan oxidation in proteins.},
  author={Parbir S Grewal and Mary Mallaney and Kimberly Y Lau and Alavattam Sreedhara},
  journal={Molecular pharmaceutics},
  year={2014},
  volume={11 4},
  pages={1259-72}
}
Oxidative damage to proteins is one of the most prominent chemical degradation pathways that are of concern for drug product development in the biotechnology industry. Especially susceptible to oxidation are the Met and Trp residues in proteins. While L-Met and L-Trp have been shown to act as antioxidants typically protecting proteins against Met and Trp oxidation, respectively, l-Trp has been shown to be particularly sensitive to light, thereby producing various reactive oxygen species (ROS… CONTINUE READING
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