Screening methods for AMP-activated protein kinase modulators: a patent review.

@article{Kim2015ScreeningMF,
  title={Screening methods for AMP-activated protein kinase modulators: a patent review.},
  author={Joungmok Kim and JoonSoo Shin and Joohun Ha},
  journal={Expert opinion on therapeutic patents},
  year={2015},
  volume={25 3},
  pages={261-77}
}
INTRODUCTION AMP-activated protein kinase (AMPK) functions as a cellular energy gauge that maintains cellular homeostasis and has been suggested to play important roles in tumorigenesis, lifespan and autophagy. Accordingly, AMPK is a potential target of drugs for controlling a growing number of human diseases ranging from metabolic disorders to cancer, highlighting the need for rational and robust screening systems for identifying compounds that modulate AMPK. AREAS COVERED The relevant… CONTINUE READING

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