Screening key lncRNAs for human lung adenocarcinoma based on machine learning and weighted gene co-expression network analysis.

  title={Screening key lncRNAs for human lung adenocarcinoma based on machine learning and weighted gene co-expression network analysis.},
  author={Ting Lei and Yu Wang and Junfeng Fu and Ze Wang and Zhenyang Lv and Zhe Fan},
  journal={Cancer biomarkers : section A of Disease markers},
  • T. Lei, Yu Wang, Z. Fan
  • Published 2019
  • Biology
  • Cancer biomarkers : section A of Disease markers
BACKGROUND Lung adenocarcinoma (LUAD) accounts for a significant proportion of lung cancer and there have been few diagnostic and therapeutic targets for LUAD due to the lack of specific biomarker. The aim of this study was to identify key long non-coding RNAs (lncRNAs) for LUAD. METHODS The lncRNA and mRNA expression profiles of a large group of patients with LUAD were obtained from The Cancer Genome Atlas (TCGA). The differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) were… 
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  • Biology, Medicine
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  • 2020
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