Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population.

Abstract

Two markers rs9652490 and rs11856808 both located in intron 3 of the LINGO1 gene have been nominated recently to be associated with essential tremor (ET). Although ET and Parkinson's disease (PD) are considered as different entities, they have many overlapping clinical and pathological features. We aimed to evaluate the role of rs9652490 and rs11856808 in the development of ET and PD. To this point, we sequenced the region involving the two markers in 109 ET cases, 425 sporadic Parkinson's disease (SPD) cases and 430 controls in Chinese population. After stratification by age, the rs9652490G allele suggested protective role in the early onset PD (EOPD, age at onset < or =50 years) group compared with age matched controls (OR=0.56, 95% CI: 0.35-0.90, p=0.015). No other significant association was found. We concluded that the two markers rs9652490 and rs11856808 were not strongly related to the development of ET or late onset SPD, but the rs9652490G allele might be a protective factor for EOPD in Chinese population.

DOI: 10.1016/j.neulet.2010.06.041
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@article{Zuo2010ScreeningFT, title={Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population.}, author={Xing Quan Zuo and Hong Jiang and Jifeng Guo and Ren-he Yu and Qi-ying Sun and Liang Hu and Lei Wang and Ling-yan Yao and Lu Shen and Qian Pan and Xin-xiang Yan and Kun Xia and B. P. Tang}, journal={Neuroscience letters}, year={2010}, volume={481 2}, pages={69-72} }