Screening for selective thrombin inhibitors in mushrooms

  title={Screening for selective thrombin inhibitors in mushrooms},
  author={Bojan Doljak and Mojca Stegnar and Uro{\vs} Urleb and Samo Kreft and Andrej Umek and M Ciglaric and B. Strukelj and Tatjana Popovi{\'c}},
  journal={Blood Coagulation and Fibrinolysis},
Thrombin is the key serine proteinase of the coagulation cascade and therefore a suitable target for inhibition of blood coagulation. A number of pharmacologically active secondary metabolites from mushrooms have already been isolated, thus providing the rationale for screening for new thrombin inhibitors in mushrooms. In this study, inhibitory activities of mushroom extracts on thrombin and trypsin were measured using the chromogenic substrates H-d-phenylalanine-l-pipecolyl-l-arginine… Expand
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