Screening for noise in gene expression identifies drug synergies

@article{Dar2014ScreeningFN,
  title={Screening for noise in gene expression identifies drug synergies},
  author={Roy D. Dar and Nina N. Hosmane and Michelle Arkin and Robert F. Siliciano and Leor S. Weinberger},
  journal={Science},
  year={2014},
  volume={344},
  pages={1392-1396}
}
Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification. We used such fluctuations to modulate reactivation of HIV from latency—a quiescent state that is a major barrier to an HIV cure. By screening a diverse library of bioactive small molecules, we identified more than 80 compounds that modulated HIV gene–expression… CONTINUE READING