Screening for methicillin-resistant Staphylococcus aureus … all doors closed?

@article{Marimuthu2014ScreeningFM,
  title={Screening for methicillin-resistant Staphylococcus aureus … all doors closed?},
  author={Kalisvar Marimuthu and Stephan Harbarth},
  journal={Current Opinion in Infectious Diseases},
  year={2014},
  volume={27},
  pages={356–362}
}
Purpose of review To describe the latest evidence for methicillin-resistant Staphylococcus aureus (MRSA) infection control strategies, with particular emphasis on active surveillance cultures with contact precautions and targeted decolonization, and their impact. Recent findings Several major trials published last year questioned the effectiveness of universal screening and contact precautions in controlling MRSA. These trials generally recommend universal decolonization as part of bundles to… 
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The effect of improved hand hygiene on nosocomial MRSA control
TLDR
In conclusion, enhancement of hand hygiene compliance has been shown to reduce MRSA rates; however, some open issues warrant further investigation.
Monitoring of multiresistant community-associated MRSA strains from patients with pathological processes of different localization
TLDR
Depending on the kind of biomaterial taken, MRSA strains, isolated from the nasal cavity, outer ear, urine samples, samples of sputum and faeces at intestinal dysbioses proved to be most resistant to the tested antimicrobial preparations.
Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase.
TLDR
The CD44-Asm-ceramide system plays an important role in the infection of macrophages with S. aureus and genetic deficiency of CD44 or Asm abrogated these signaling events and thereby reduced internalization of S.aureus into macrophage by 60-80%.
Multiresistente Erreger (MRSA, VRE, MRGN)
TLDR
Durch die konsequente Durchfuhrung der Basishygiene und gezielte Masnahmen der Flachendesinfektion konnen Transmissionen and resultierend Infektionen sowohl with VRE als auch with sensiblen Enterokokken reduziert werden.
Prävention der Transmission von multiresistenten Erregern
TLDR
Studies evaluating infection control measures for methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and multidrug-resistant Gram-negative bacteria differ with respect to the prevalence of MDR, screening methods, number of available personnel and compliance with hand hygiene measures.

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