Screening for low aquatic bioaccumulation. 1. Lipinski's 'Rule of 5' and molecular size.

Aquatic bioconcentration factors are critical in PBT assessment of industrial chemicals under REACH. Reliable indicators based on physico-chemical properties and molecular attributes of chemicals with low bioconcentration potential have been searched to de-prioritize non-accumulative chemicals in order to avoid unnecessary biotests that do not produce risk… CONTINUE READING