Screening for late neonatal vitamin K deficiency by acarboxyprothrombin in dried blood spots.

@article{Motohara1987ScreeningFL,
  title={Screening for late neonatal vitamin K deficiency by acarboxyprothrombin in dried blood spots.},
  author={Kunihiko Motohara and Fumio Endo and Ichiro Matsuda},
  journal={Archives of disease in childhood},
  year={1987},
  volume={62 4},
  pages={
          370-5
        }
}
Acarboxyprothrombin (protein induced by vitamin K absence or antagonist-II (PIVKA-II] concentrations in dried blood spots were determined in 19,029 infants at about 1 month of age as an indicator of vitamin K deficiency. We observed 51 cases with raised blood concentrations of PIVKA-II (greater than 4 AU/ml), nine of whom showed very high concentrations (greater than 20 AU/ml). For infants who did not receive vitamin K prophylaxis at birth, the incidence of the PIVKA-II test yielding positive… CONTINUE READING

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