Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary.

  title={Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary.},
  author={Samuel M Cohen},
  journal={Toxicology research},
  volume={7 4},
  • Samuel M Cohen
  • Published in Toxicology research 2018
  • Biology, Medicine
  • Screening for carcinogens in general, and for the urinary bladder specifically, traditionally involves a two-year bioassay in rodents, the results of which often do not have direct relevance to humans with respect to mode of action (MOA) and/or dose response. My proposal describes a multi-step short-term (90 day) screening process that characterizes known human urinary bladder carcinogens, and identifies those reported in rodent two-year bioassays. The initial step is screening for urothelial… CONTINUE READING

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