Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase.

@article{Paterson2000ScreeningFG,
  title={Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase.},
  author={Joan Paterson and Francis Toolis},
  journal={Gut},
  year={2000},
  volume={46 5},
  pages={707-10}
}
BACKGROUND In the UK approximately 1 in 140 people are homozygous for the C282Y mutation of the HFE gene and are at risk from iron overload caused by genetic haemochromatosis (GH). Early detection can prevent organ damage secondary to iron deposition and increase life expectancy. AIM To screen for GH in all blood samples sent to the laboratory for routine liver function tests in which raised serum alanine aminotransferase (ALT) activity was detected. METHODS ALT was measured in sera sent to… CONTINUE READING