• DOI:10.1016/S0887-2333(96)00047-1
Corpus ID: 22770954

Screening for drug-induced alterations in the production and release of steroid hormones by porcine adrenocortical cells in vitro.

@article{Jager1996ScreeningFD,
  title={Screening for drug-induced alterations in the production and release of steroid hormones by porcine adrenocortical cells in vitro.},
  author={L. Jager and G. de Graaf and H. Widjaja-Greefkes},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1996},
  volume={10 5},
  pages={
          595-608
        }
}

L. Jager, G. de Graaf, H. Widjaja-Greefkes

Published 1996

Biology, Medicine

Toxicology in vitro : an international journal published in association with BIBRA

To screen drugs rapidly and at minimal expense for their potential to alter steroidogenesis, an in vitro model using porcine adrenocortical cells was developed. Pregnenolone, progesterone, deoxycorticosterone or corticosterone (all at 1 muM) were used as substrates. Drug-induced changes in the production/release of aldosterone were measured after 1-hr incubation. With pregnenolone, drug-induced effects on the release of nine steroids (aldosterone, corticosterone, cortisol, deoxycortisol… CONTINUE READING

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