Screening for drug-induced alterations in the production and release of steroid hormones by porcine adrenocortical cells in vitro.

@article{Jager1996ScreeningFD,
  title={Screening for drug-induced alterations in the production and release of steroid hormones by porcine adrenocortical cells in vitro.},
  author={L. Jager and G. de Graaf and H. Widjaja-Greefkes},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={1996},
  volume={10 5},
  pages={
          595-608
        }
}
  • L. Jager, G. de Graaf, H. Widjaja-Greefkes
  • Published 1996
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • To screen drugs rapidly and at minimal expense for their potential to alter steroidogenesis, an in vitro model using porcine adrenocortical cells was developed. Pregnenolone, progesterone, deoxycorticosterone or corticosterone (all at 1 muM) were used as substrates. Drug-induced changes in the production/release of aldosterone were measured after 1-hr incubation. With pregnenolone, drug-induced effects on the release of nine steroids (aldosterone, corticosterone, cortisol, deoxycortisol… CONTINUE READING
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