Screening for cystic fibrosis in the newborn by meconium analysis.

  title={Screening for cystic fibrosis in the newborn by meconium analysis.},
  author={Henry C. Ryley and L M Neale and T D Brogan and P T Bray},
  journal={Archives of disease in childhood},
  volume={54 2},
During a 4-year routine screening programme for cystic fibrosis (CF) 15 464 specimens were examined for raised meconium albumin levels by a test strip method and by electroimmunoassay. The incidence of false-positive results was about 5 per 1000 specimens in either test. This could be reduced by 90% by determining the ratio of albumin : alpha-1-trypsin inhibitor (a ratio below 2.0 being considered as a negative result), and it could be reduced to zero by determining the ratio in subsequent… CONTINUE READING