Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia--a comparative study of four differently designed, high resolution microarray platforms.

@article{Gunnarsson2008ScreeningFC,
  title={Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia--a comparative study of four differently designed, high resolution microarray platforms.},
  author={Rebeqa Gunnarsson and Johan Staaf and Mattias Jansson and Anne Marie Ottesen and Hanna G{\"o}ransson and Ulrika Liljedahl and Ulrik Ralfkiaer and Mahmoud Reza Mansouri and Anne Mette Buhl and Karin Ekstr{\"o}m Smedby and Henrik Hjalgrim and Ann-Christine Syv{\"a}nen and {\AA}ke Borg and Anders Isaksson and Jesper Jurlander and Gunnar Juliusson and Richard Rosenquist},
  journal={Genes, chromosomes & cancer},
  year={2008},
  volume={47 8},
  pages={697-711}
}
Screening for gene copy-number alterations (CNAs) has improved by applying genome-wide microarrays, where SNP arrays also allow analysis of loss of heterozygozity (LOH). We here analyzed 10 chronic lymphocytic leukemia (CLL) samples using four different high-resolution platforms: BAC arrays (32K), oligonucleotide arrays (185K, Agilent), and two SNP arrays (250K, Affymetrix and 317K, Illumina). Cross-platform comparison revealed 29 concordantly detected CNAs, including known recurrent… CONTINUE READING
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