Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA

@article{Wieczorek2004ScreeningFC,
  title={Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA},
  author={Stefan Wieczorek and Peter Jagiello and Larissa Arning and Norbert Dahmen and J{\"o}rg T. Epplen},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={82},
  pages={696-705}
}
Narcolepsy is a complex sleep disorder characterized by excessive daytime sleepiness and cataplexy. Mutations in genes of the hypocretin (orexin) neurotransmitter system cause narcoleptic symptoms in animal models. The absence of hypocretin in the cerebrospinal fluid of human patients is hypothesized to originate from destruction of hypocretinergic cells in the hypothalamus, the cause of which remains unknown. Due to strong HLA association autoimmune models of narcolepsy pathogenesis are still… CONTINUE READING