Screening for an inherited susceptibility to colorectal cancer.

  title={Screening for an inherited susceptibility to colorectal cancer.},
  author={PeterT. Rowley},
  journal={Genetic testing},
  volume={8 4},
The principal Mendelian disorders predisposing to colorectal cancer are familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). FAP is caused by mutations in the adenomatous polyposis coli (APC) gene. HNPCC is caused by a mutation in one of at least five mismatch repair genes. It is important to identify individuals with these conditions because colon cancer will occur in at least 80% and onset is earlier than in the general population. Potential benefits of… CONTINUE READING