Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model.

@article{Pandharipande2015ScreeningFP,
  title={Screening for Pancreatic Adenocarcinoma in BRCA2 Mutation Carriers: Results of a Disease Simulation Model.},
  author={Pari Vijay Pandharipande and Alvin Jeon and Curtis R Heberle and Emily C. Dowling and Chung Yin Kong and Daniel C. Chung and William Robert Brugge and Chin Hur},
  journal={EBioMedicine},
  year={2015},
  volume={2 12},
  pages={1980-6}
}
BACKGROUND BRCA2 mutation carriers are at increased risk for multiple cancers including pancreatic adenocarcinoma (PAC). Our goal was to compare the effectiveness of different PAC screening strategies in BRCA2 mutation carriers, from the standpoint of life expectancy. METHODS A previously published Markov model of PAC was updated and extended to incorporate key aspects of BRCA2 mutation carrier status, including competing risks of breast- and ovarian-cancer specific mortality. BRCA2 mutation… CONTINUE READING
4 Citations
27 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Evolution of the Whipple procedure at the Massachusetts General Hospital

  • J. F. Finks, N. H. Osborne, J. D. Birkmeyer
  • Surgery
  • 2011
2 Excerpts

Similar Papers

Loading similar papers…