Screening for Lynch Syndrome in Colorectal Cancer: Are We Doing Enough?

  title={Screening for Lynch Syndrome in Colorectal Cancer: Are We Doing Enough?},
  author={Guillaume Canard and Jeremie H Lefevre and Chrystelle Colas and PhD Florence Coulet PharmD and PhD Magali Svrcek and Olivier Lascols and Richard C Hamelin and Conor J. Shields and PhD Alex Duval and PhD Jean-François Flejou and PhD Florent Soubrier and Emmanuel Tiret and PhD Yann Parc},
  journal={Annals of Surgical Oncology},
The purpose of this study was to assess the efficacy of screening for the detection of Lynch syndrome (LS) in an unselected population undergoing surgery for a colorectal cancer. A total of 1,040 patients were prospectively included between 2005 and 2009. LS screening modalities included the Bethesda criteria, immunochemistry (IHC) for MLH1, MSH2, and MSH6, and microsatellite instability (MSI) by using pentaplex markers. Promoter methylation was assessed in tumors with a loss of MLH1 expression… CONTINUE READING