Screening for GPCR Ligands Using Surface Plasmon Resonance

  title={Screening for GPCR Ligands Using Surface Plasmon Resonance},
  author={Iva Navratilova and J{\'e}r{\'e}my Besnard and Andrew L. Hopkins},
  booktitle={ACS medicinal chemistry letters},
G-protein coupled receptors (GPCRs) are a class of drug targets of primary importance. However, receptor assays are based on measurement of either ligand displacement or downstream functional responses, rather than direct observation of ligand binding. Issues of allosteric modulation, probe dependence, and functional selectivity create challenges in selecting suitable assays formats. Therefore, a method that directly measures GPCR-ligand interactions, independent of binding site, probe, and… CONTINUE READING
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