Screening for EGFR and KRAS Mutations in Endobronchial Ultrasound Derived Transbronchial Needle Aspirates in Non-Small Cell Lung Cancer Using COLD-PCR

@article{Santis2011ScreeningFE,
  title={Screening for EGFR and KRAS Mutations in Endobronchial Ultrasound Derived Transbronchial Needle Aspirates in Non-Small Cell Lung Cancer Using COLD-PCR},
  author={G. Santis and R. Angell and G. Nickless and A. Quinn and A. Herbert and P. Cane and J. Spicer and R. Breen and E. Mclean and K. Tobal},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • G. Santis, R. Angell, +7 authors K. Tobal
  • Published 2011
  • Medicine
  • PLoS ONE
  • EGFR mutations correlate with improved clinical outcome whereas KRAS mutations are associated with lack of response to tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). Endobronchial ultrasound (EBUS)-transbronchial needle aspiration (TBNA) is being increasingly used in the management of NSCLC. Co-amplification at lower denaturation temperature (COLD)–polymerase chain reaction (PCR) (COLD-PCR) is a sensitive assay for the detection of genetic mutations in solid… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 53 REFERENCES
    EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
    • 8,471
    • PDF
    Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma.
    • 4,681
    First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations.
    • 766
    KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
    • 1,018
    • PDF