Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

@article{Irvine2017ScreeningFC,
  title={Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis},
  author={Andrew J. Irvine and William D. Chey and Alexander Charles Ford},
  journal={The American Journal of Gastroenterology},
  year={2017},
  volume={112},
  pages={65-76}
}
Objectives:Celiac disease (CD) and irritable bowel syndrome (IBS) share similar symptoms, leading to confusion between the two and diagnostic delay. International guidelines recommend screening individuals with IBS for CD, via serological testing. However, studies published recently have cast doubt on the utility of this. We updated a previous meta-analysis examining this issue.Methods:MEDLINE, EMBASE, and EMBASE Classic were searched through to May 2016. Eligible studies recruited adults with… 
Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria
TLDR
Positive serology and biopsy results suggestive of CD are common among patients with IBS, and Screening patientswith IBS for CD is justified.
Celiac disease is uncommon in irritable bowel syndrome in the USA
TLDR
The findings do not support routine celiac serologic or genetic testing in patients with IBS in all US populations.
Undiagnosed Celiac Disease In Patients Presenting With Irritable Bowel Syndrome Symptoms.
  • Y. Khayyat
  • Medicine
    Journal of Ayub Medical College, Abbottabad : JAMC
  • 2020
TLDR
Serology screening for CD is helpful in IBS and IBS-D patients and no correlation was found between tTG positivity and age and sex of the case group.
ACG Clinical Guideline: Management of Irritable Bowel Syndrome.
TLDR
This first-ever American College of Gastroenterology clinical guideline for the management of IBS recommends that a positive diagnostic strategy as compared to a diagnostic strategy of exclusion be used to improve time to initiating appropriate therapy and recommends gut-directed psychotherapy to treat global IBS symptoms.
The seroprevalence of celiac disease in patients with symptoms of irritable bowel syndrome: A cross-sectional study in north of Iran.
TLDR
Physicians are suggested to consider celiac examinations for all patients with IBS symptoms, even for patients with no obvious celiac symptoms.
A systematic review and meta-analysis on the prevalence of non-malignant, organic gastrointestinal disorders misdiagnosed as irritable bowel syndrome
TLDR
The prevalence of five gastrointestinal conditions—bile acid diarrhoea (BAD), carbohydrate malabsorption (CM), microscopic colitis (MC), pancreatic exocrine insufficiency (PEI) and small intestinal bacterial overgrowth (SIBO) was systematically assessed from studies including consecutive patients meeting diagnostic criteria for IBS.
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TLDR
A high prevalence of celiac disease in irritable bowel syndrome patients in Iran is observed, which is higher than global estimates and Examination of all IBS patients in terms of CD seems to be necessary, but cost-effectiveness should be considered.
Rational investigations in irritable bowel syndrome
TLDR
Patients with IBS should have a faecal calprotectin measured, and should proceed to colonoscopy to exclude inflammatory bowel disease (IBD) if this is positive, and the need for investigations should be made on a case-by-case basis, contingent on the reporting of known risk factors for organic pathology.
Review article: Diagnosis and investigation of irritable bowel syndrome
  • C. Black
  • Medicine
    Alimentary pharmacology & therapeutics
  • 2021
TLDR
Adopting a standardised approach to the diagnosis and investigation of IBS will help to promote high‐quality and high‐value care for patients overall.
Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia
TLDR
Adherence to clinical recommendations can facilitate timely diagnosis and improve medical aid quality in patients with different clinical IBS variants.
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