Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement

@article{BibbinsDomingo2017ScreeningFC,
  title={Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement},
  author={Kirsten Bibbins-Domingo and David C. Grossman and Susan J Curry and Michael J. Barry and Karina W. Davidson and Chyke A Doubeni and Mark H. Ebell and John W Epling and Jessica Herzstein and Alex R. Kemper and Alex H. Krist and Ann E. Kurth and C. Seth Landefeld and Carol M. Mangione and Maureen G. Phipps and Michael Silverstein and Melissa A Simon and Chien-Wen Tseng},
  journal={JAMA},
  year={2017},
  volume={317},
  pages={1252–1257}
}
Importance Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. Objective To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. Evidence Review The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic… Expand
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The US Preventive Services Task Force Recommendation on Screening for Asymptomatic Celiac Disease: A Dearth of Evidence.
TLDR
The USPSTF concludes that “the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons” and has recommended that more research is needed in this area. Expand
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Although both conditions are treated with a gluten-free diet, distinguishing between celiac disease and nonceliac gluten sensitivity is important for long-term therapy. Expand
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Current understanding of celiac disease continues to advance, though significant knowledge gaps remain and large, rigorous, prospectively designed studies are needed to further characterize Celiac disease pathogenesis, management and therapeutic options. Expand
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TLDR
An increased willingness to screen when participants were faced with increasing hypothetical risks suggests that screening recommendations targeting high-risk populations, such as those of paediatric and non-paediatric gastroenterology societies, may be more widely accepted. Expand
Epidemiology, Presentation, and Diagnosis of Celiac Disease.
TLDR
If proven accurate and scalable, assays that detect gluten-HLA tetramer complexes might be used in diagnosis to be made in the context of a gluten-free diet, without intestinal biopsy. Expand
Routine Screening for Celiac Disease in Children with Down Syndrome Improves Case Finding.
TLDR
The results suggest the need for routine celiac disease screening in children with Down syndrome to improve case-finding and avoid diagnostic delay. Expand
Is There a Role of Using a Rapid Finger Prick Antibody Test in Screening for Celiac Disease in Children?
TLDR
The results have not confirmed the usefulness of the POC test in screening the general population of first-grade schoolchildren, and further research is needed to establish the true epidemiology of CD in Primorje-Gorski Kotar County. Expand
Coeliac disease
TLDR
The risk factors and immune mechanisms of coeliac disease are discussed, future treatment options beyond the gluten-free diet are highlighted and the diet is restrictive and gluten is difficult to avoid. Expand
Prevalence of occult celiac disease in females with iron deficiency in the United States: an NHANES analysis
TLDR
The overall prevalence of celiac disease in the USA’ female population is low, however, the prevalence is higher in subjects with iron deficiency, and the prevalence of CD was higher in female subjects with ID. Expand
Low Rates of Screening for Celiac Disease Among Family Members
TLDR
It is found that nearly 30% of symptomatic first‐degree relatives of patients with celiac disease have not received the tests recommended by guidelines, and health care providers should implement strategies to identify and screen patients at increased risk for Celiac disease. Expand
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TLDR
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